| Don Karnes | |
| Birth Date: | 28 September 1902 |
| Birth Place: | Fairbury, Illinois, U.S. |
| Death Place: | Fairbury, Illinois, U.S. |
| Player Sport1: | Basketball |
| Player Years2: | 1923–1925 |
| Player Team2: | Illinois |
| Player Positions: | Forward |
| Coach Sport1: | Football |
| Coach Years2: | 1925–1926 |
| Coach Team2: | Illinois State |
| Coach Sport3: | Basketball |
| Coach Years4: | 1925–1926 |
| Coach Team4: | Illinois State |
| Overall Record: | 5–10 (football) 9–20 (basketball) |
Thomas Donald Karnes (September 28, 1902 – April 23, 1982) was an American football and basketball coach. He was the tenth head football coach at Illinois State Normal University—now known as Illinois State University—in Normal, Illinois, serving for two seasons, from 1925 to 1926, and compiling a record of 5–10.[1] Karnes was also the head basketball coach at Illinois State from 1925 to 1927, tallying a mark of 9–20.
In 1955, he immigrated to Brazil.