| Office: | First Lady of Venezuela |
| President: | José Antonio Páez |
| Term Label1: | In role |
| Term Start1: | 13 January 1830 |
| Term End1: | 20 January 1835 |
| Predecessor1: | Position created |
| Successor1: | Encarnación Maitín |
| Term Label2: | In role |
| Term Start2: | 1 February 1839 |
| Term End2: | 28 January 1843 |
| Predecessor2: | Olalla Buroz y Tovar |
| Successor2: | Olalla Buroz y Tovar |
| Term Label3: | In role |
| Term Start3: | 29 August 1861 |
| Term End3: | 15 June 1863 |
| Predecessor3: | Encarnación Rivas Pacheco |
| Successor3: | Luisa Isabel Pachano Muñoz |
| Term Label: | In role |
| Birth Name: | Dominga Ortiz Orzúa |
| Birth Date: | 1 November 1792 |
| Birth Place: | Canaguá, Barinas, Captaincy General of Venezuela |
| Death Place: | Caracas, Venezuela |
| Party: | Conservative |
| Spouse: | José Antonio Páez (18??; died 1873) |
| Children: | 2 |
Dominga Ortiz Orzúa (November 1, 1792 - December 31, 1875) was three-time First Lady of Venezuela.[1] She was born in Canaguá, Barinas, Captaincy General of Venezuela in 1792 and died in Caracas, Venezuela in 1875.
Married to President José Antonio Páez, she had two children, Manuel A. Páez and María del Rosario Páez de Llamosas.