| Type: | Cardinal |
| Honorific Prefix: | His Eminence |
| Domenico de Simone | |
| Cardinal-Deacon of Sant'Angelo in Pescheria | |
| Church: | Roman Catholic Church |
| Appointed: | 5 July 1830 |
| Term End: | 9 November 1837 |
| Predecessor: | Alphonse-Hubert de Latier de Bayane |
| Successor: | Luigi Ciacchi |
| Cardinal: | 15 March 1830 |
| Created Cardinal By: | Pope Pius VIII |
| Rank: | Cardinal-Deacon |
| Birth Name: | Domenico de Simone |
| Birth Date: | 29 November 1768 |
| Birth Place: | Benevento, Kingdom of Naples |
| Death Place: | Rome, Papal States |
| Buried: | Sant'Angelo in Pescheria |
| Parents: | Filippo de Simone Vicenza Capece Scondito |
| Alma Mater: | Pontifical Academy of Ecclesiastical Nobles |
| Previous Post: | Camerlengo of the College of Cardinals (1832-33) |
| Cardinal Name: | Domenico de Simone |
| Dipstyle: | His Eminence |
| Offstyle: | Your Eminence |
| See: | Prefect of Papal Household |
Domenico de Simone (29 November 1768 - 9 November 1837) was an Italian cardinal. He was part of the Roman Curia.[1] [2]
He was born in Benevento and died in Rome.
He was made a cardinal in March 1830 by Pope Pius VIII and took part in the 1830–1831 conclave which chose Pope Gregory XVI.[3] [4]