| Type: | Cardinal |
| Honorific Prefix: | His Eminence |
| Domenico Sanguigni | |
| Cardinal-Priest of Santa Pudenziana | |
| Church: | Roman Catholic Church |
| Appointed: | 27 February 1880 |
| Term End: | 20 November 1882 |
| Predecessor: | Lucien Bonaparte |
| Successor: | Włodzimierz Czacki |
| Consecration: | 23 August 1874 |
| Consecrated By: | Alessandro Franchi |
| Cardinal: | 19 September 1879 |
| Created Cardinal By: | Pope Leo XIII |
| Rank: | Cardinal-Priest |
| Birth Name: | Domenico Sanguigni |
| Birth Date: | 27 June 1809 |
| Birth Place: | Terracina, Papal States |
| Death Place: | Rome, Kingdom of Italy |
Domenico Sanguigni (27 June 1809 – 20 November 1882) was an Italian cardinal and apostolic nuncio.