| dolichyl-diphosphooligosaccharide-protein glycotransferase | |
| Ec Number: | 2.4.99.18 |
| Cas Number: | 75302-32-8 |
| Go Code: | 0004579 |
| Oligosaccaryltransferase | |
| Interpro: | IPR018943 |
| Opm Family: | 242 |
| Opm Protein: | 2lat |
| Membranome Superfamily: | 275 |
In enzymology, a dolichyl-diphosphooligosaccharide–protein glycotransferase is an enzyme that catalyzes the chemical reaction
dolichyl diphosphooligosaccharide + protein L-asparagine
\rightleftharpoons
Thus, the two substrates of this enzyme are dolichyl diphosphooligosaccharide and protein L-asparagine, whereas its 3 products are dolichyl diphosphate, glycoprotein with the oligosaccharide chain attached by N-glycosyl, and linkage to protein L-asparagine.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase. Other names in common use include dolichyldiphosphooligosaccharide-protein glycosyltransferase, asparagine N-glycosyltransferase, dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase, dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase, oligomannosyltransferase, oligosaccharide transferase, dolichyldiphosphoryloligosaccharide-protein, and oligosaccharyltransferase. This enzyme participates in n-glycan biosynthesis and glycan structures - biosynthesis 1.