Dolichyl-phosphate beta-D-mannosyltransferase explained
| dolichyl-phosphate beta-D-mannosyltransferase |
| Ec Number: | 2.4.1.83 |
| Cas Number: | 62213-44-9 |
| Go Code: | 0004582 |
In enzymology, a dolichyl-phosphate beta-D-mannosyltransferase is an enzyme that catalyzes the chemical reaction
GDP-mannose + dolichyl phosphate
GDP + dolichyl D-mannosyl phosphate
Thus, the two substrates of this enzyme are GDP-mannose and dolichyl phosphate, whereas its two products are GDP and dolichyl D-mannosyl phosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase. Other names in common use include GDP-Man:DolP mannosyltransferase, dolichyl mannosyl phosphate synthase, dolichyl-phospho-mannose synthase, GDP-mannose:dolichyl-phosphate mannosyltransferase, guanosine diphosphomannose-dolichol phosphate mannosyltransferase, dolichol phosphate mannose synthase, dolichyl phosphate mannosyltransferase, dolichyl-phosphate mannose synthase, GDP-mannose-dolichol phosphate mannosyltransferase, GDP-mannose-dolichylmonophosphate mannosyltransferase, mannosylphosphodolichol synthase, and mannosylphosphoryldolichol synthase. This enzyme participates in n-glycan biosynthesis.
References
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- Bretthauer RK, Wu S, Irwin WE . 1973 . Enzymatic transfer of mannose from guanosine diphosphate mannose to dolichol phosphate in yeast (Hansenula holstii). A possible step in mannan synthesis . Biochim. Biophys. Acta . 304 . 736 - 47 . 4726855 . 3 . 10.1016/0304-4165(73)90220-1.
- Haselbeck A . 1989 . Purification of GDP mannose:dolichyl-phosphate O-beta-D-mannosyltransferase from Saccharomyces cerevisiae . Eur. J. Biochem. . 181 . 663 - 8 . 2659345 . 10.1111/j.1432-1033.1989.tb14774.x . 3 . free .
- Palamarczyk G, Lehle L, Mankowski T, Chojnacki T, Tanner W . 1980 . Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives . Eur. J. Biochem. . 105 . 517 - 23 . 6445267 . 10.1111/j.1432-1033.1980.tb04527.x . 3 . free .
- Richards JB, Hemming FW . 1972 . The transfer of mannose from guanosine diphosphate mannose to dolichol phosphate and protein by pig liver endoplasmic reticulum . Biochem. J. . 130 . 77 - 93 . 4655455 . 1 . 1174303 .
