Docosatetraenoylethanolamide Explained

Docosatetraenoylethanolamide (DEA) (Adrenoyl-ethanolamide) (Adrenoyl-EA) is an endogenous ethanolamide that has been shown to act on the cannabinoid (CB1) receptor.[1] DEA is similar in structure to anandamide (AEA, a recognized endogenous ligand for the CB1 receptor), containing docosatetraenoic acid in place of arachidonic acid. While DEA has been shown to bind to the CB1 receptor with similar potency and efficacy as AEA, its role as a cannabinergic neurotransmitter is not well understood.

Docosatetraenoylethanolamide (DEA) has been found in Tropaeolum tuberosum (Mashua) and Leonotis leonurus (Wild Dagga / Lion's Tail).[2]

Notes and References

  1. Hanus, L. . Gopher, A. . Almog, S. . 1993. Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor. J Med Chem. 36. 3032–3034. 10.1021/jm00072a026. 8411021. 20. etal.
  2. Toward the identification of a phytocannabinoid-like compound in the flowers of a South African medicinal plant (Leonotis leonurus) . 10.1186/s13104-020-05372-z. 2020 . Hunter . E. . Stander . M. . Kossmann . J. . Chakraborty . S. . Prince . S. . Peters . S. . Loedolff . Bianke . BMC Research Notes . 13 . 1 . 522 . 33172494 . 7653773 . free .

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