Dock4-Ex49 Explained

Dock4-Ex49 is a splice variant of the signalling protein Dock4 (Dedicator of cytokinesis 4). It has been found in the brain, inner ear and eye.^[1] It is able to bind and activate the small G protein Rac and may regulate the organisation of the actin cytoskeleton in the Stereocilia of the inner ear.

Notes and References

1. Yan D, Li F, Hall ML . An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C). J. Mol. Biol. . 357 . 3 . 755–64 . March 2006 . 16464467 . 10.1016/j.jmb.2006.01.017. etal.