| Doce de Octubre Department | |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Mapsize: | 180px |
| Pushpin Map Caption: | Location of Doce de Octubre Department in Argentina |
| Coordinates: | -27.3167°N -76°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Chaco Province |
| Established Date: | 1912-05-25 |
| Seat Type: | Head town |
| Unit Pref: | Metric |
| Area Total Km2: | 2,576 |
| Population Total: | 20,149 |
| Population Density Km2: | auto |
| Population Demonym: | Pinedense |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code: | H3732 |
| Area Code: | 03731 |
12 de Octubre is a western department of Chaco Province in Argentina.
The provincial subdivision has a population of about 20,000 inhabitants in an area of 2,576 km2, and its capital city is General Pinedo, which is located around 1,060 km from the Capital federal.