| Ruxandra of Moldavia | |
| Succession: | Regent of Moldavia |
| Reign: | 1568–1570 |
| Reign-Type: | Regency |
| Regent: | Bogdan IV of Moldavia |
| Reg-Type: | Prince |
| Succession1: | Princess Consort of Moldavia (1st reign) |
| Reign1: | 1556–1561 |
| Reign-Type1: | Tenure |
| Succession2: | Princess Consort of Moldavia (2nd reign) |
| Reign2: | 1564–1568 |
| Reign-Type2: | Tenure |
| Father: | Petru Rareș of Moldavia |
| Mother: | Doamna Jelena Branković of Serbia |
| Spouse: | Alexandru Lăpușneanu |
| Issue: | Bogdan IV of Moldavia |
| Birth Date: | 1538 |
| Birth Place: | Suceava, Principality of Moldavia |
| Death Place: | Iași, Principality of Moldavia |
| House: | House of Mușat |
Ruxandra Lăpușneanu (1538 – 21 November 1570) was a princess consort of Moldavia by her marriage to Alexandru Lăpușneanu in 1564. Ruxandra was the daughter of Peter IV Rareș and Princess Elena Ecaterina Rareș (the second daughter of Jovan Branković of Serbia). From 1568 until 1570 she was regent in Moldavia on behalf of her son Bogdan IV of Moldavia.