DnaN explained
| DNA polymerase III subunit beta |
| Symbol: | dnaN |
| Organism: | Escherichia coli
(str. K-12 substr. MG1655) |
| Taxid: | 511145 |
| Entrezgene: | 948218 |
| Pdb: | 1MMI |
| Refseqprotein: | NP_418156 |
| Uniprot: | P0A988 |
| Ecnumber: | 2.7.7.7 |
| Chromosome: | MG1655 |
| Entrezchromosome: | NC_000913 |
| Genloc Start: | 3879078 |
| Genloc End: | 3880508 |
dnaN is the gene that codes for the DNA clamp (also known as β sliding clamp) of DNA polymerase III in prokaryotes.[1] [2] The β clamp physically locks Pol III onto a DNA strand during replication to help increase its processivity.[3] The eukaryotic equivalent to the β clamp is PCNA.
See also
Notes and References
- Ohmori H, Kimura M, Nagata T, Sakakibara Y . Structural analysis of the dnaA and dnaN genes of Escherichia coli . Gene . 28 . 2 . 159–70 . May 1984 . 6234204 . 10.1016/0378-1119(84)90253-1.
- Armengod ME, García-Sogo M, Lambíes E . Transcriptional organization of the dnaN and recF genes of Escherichia coli K-12 . J. Biol. Chem. . 263 . 24 . 12109–14 . August 1988 . 2841344 .
- Stukenberg PT, Studwell-Vaughan PS, O'Donnell M . Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme . J. Biol. Chem. . 266 . 17 . 11328–34 . June 1991 . 2040637 .
