DmpG-like communication domain explained

Symbol:DmpG_comm
DmpG-like communication domain
Pfam:PF07836
Interpro:IPR012425
Scop:1nvm

In molecular biology, the DmpG-like communication domain is a protein domain found towards the C-terminal region of various aldolase enzymes. It consists of five alpha-helices, four of which form an antiparallel helical bundle that plugs the C terminus of the N-terminal TIM barrel domain.[1] The communication domain is thought to play an important role in the heterodimerisation of the enzyme.[1]

This domain heterodimerises with acetaldehyde dehydrogenases to form a bifunctional aldolase-dehydrogenase.[1]

Notes and References

  1. Manjasetty BA, Powlowski J, Vrielink A . Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate . Proc. Natl. Acad. Sci. U.S.A. . 100 . 12 . 6992–7 . June 2003 . 12764229 . 165818 . 10.1073/pnas.1236794100 . free .

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