Discodermia Explained

Discodermia is a genus of deep-water sea sponge.[1]

Species

The following species are accepted within Discodermia:

Pharmacology

thumb|Discodermins B-DD. dissoluta is of interest to bio and organic chemists because it produces (+)-discodermolide, a polyketide natural product with immunosuppressive and cancer killing properties.[2]

Antimicrobial/anticancer peptides called discodermins have been isolated from D. kiiensis.[3]

Notes and References

  1. Brück WM, Sennett SH, Pomponi SA, Willenz P, McCarthy PJ. 2008. Identification of the bacterial symbiont Entotheonella sp. in the mesohyl of the marine sponge Discodermia sp.. The ISME Journal. 2. 3. 335–339. 10.1038/ismej.2007.91. 18256706. free. 2008ISMEJ...2..335B .
  2. Singh R, Sharma M, Joshi P, Rawat DS. 2008. Clinical status of anti-cancer agents derived from marine sources. Anti-Cancer Agents in Medicinal Chemistry. 8. 6. 603–617. 10.2174/187152008785133074. 18690825.
  3. 20065108. 2010. Otero-González. AJ. Magalhaes. BS. Garcia-Villarino. M. Lopez-Abarrategui. C . Sousa . DA . Dias . SC . Franco . OL . Antimicrobial peptides from marine invertebrates as a new frontier for microbial infection control. 24. 5. 1320–34. 10.1096/fj.09-143388. FASEB Journal. free . 23976702.