| Official Name: | Dios le Guarde |
| Settlement Type: | municipality |
| Flag Size: | 150 |
| Pushpin Map: | Spain |
| Pushpin Map Caption: | Location in Spain |
| Coordinates: | 40.6425°N -6.3144°W |
| Subdivision Type: | Country |
| Subdivision Name: | Spain |
| Subdivision Type1: | Autonomous community |
| Subdivision Name1: | Castile and León |
| Subdivision Type2: | Province |
| Subdivision Name2: | Salamanca |
| Subdivision Type3: | Comarca |
| Subdivision Name3: | Comarca de Ciudad Rodrigo |
| Subdivision Type4: | Subcomarca |
| Subdivision Name4: | Campo del Yeltes |
| Leader Party: | People's Party |
| Leader Title: | Mayor |
| Leader Name: | Luis Sánchez García |
| Area Total Km2: | 16 |
| Elevation M: | 814 |
| Population Density Km2: | auto |
| Timezone: | CET |
| Utc Offset: | +1 |
| Timezone Dst: | CEST |
| Utc Offset Dst: | +2 |
| Postal Code Type: | Postal code |
| Postal Code: | 37478 |
| Area Footnotes: | [1] |
Dios le Guarde is a village and municipality in the province of Salamanca, western Spain, part of the autonomous community of Castile-Leon. It is located from the provincial capital city of Salamanca and as of 2016 has a population of 139 people.
The name came from Old Spanish meaning "God's Guard".
The municipality covers an area of 16km2. It lies above sea level and the postal code is 37478.