| Jurisdiction: | Diocese |
| Melipilla | |
| Latin: | Dioecesis Melipillensis |
| Local: | Diócesis de Melipilla |
| Sui Iuris Church: | Latin Church |
| Rite: | Roman Rite |
| Established: | 4 April 1991 (years ago) |
| Cathedral: | Cathedral of St Joseph in Melipilla |
| Area Km2: | 6,217 |
| Population: | 482,462 |
| Population As Of: | 2004 |
| Catholics: | 385,970 |
| Catholics Percent: | 80.0 |
| Bishop: | Cristián Contreras Villarroel |
| Website: | www.iglesiademelipilla.cl |
The Roman Catholic Diocese of Melipilla (Latin: Melipillen(sis)) is a diocese located in the city of Melipilla in the ecclesiastical province of Santiago de Chile in Chile.