| Jurisdiction: | Diocese |
| Huajuapan de León | |
| Latin: | Dioecesis Huaiuapanensis |
| Local: | Diócesis de Huajuapan de León |
| Country: | Mexico |
| Province: | Puebla de los Ángeles |
| Area Sqmi: | 10,042 |
| Population: | 760,000 |
| Population As Of: | 2006 |
| Catholics: | 720.000 |
| Catholics Percent: | 94.7 |
| Parishes: | 71 |
| Denomination: | Catholic Church |
| Sui Iuris Church: | Latin Church |
| Rite: | Roman Rite |
| Established: | 25 April 1902 (years ago) |
| Cathedral: | Cathedral of the Virgin of Guadalupe |
| Bishop: | Miguel Ángel Castro Muñoz |
| Metro Archbishop: | Victor Sánchez Espinosa |
| Map: | Roman Catholic Diocese of Huajuapan in Mexico.jpg |
| Website: | arquidiocesisdepuebla.mx |
The Diocese of Huajuapan de León (Latin: Dioecesis Huaiuapanensis) is a Latin Church ecclesiastical territory or diocese of the Catholic Church in Mexico. The diocese is a suffragan in the ecclesiastical province of the metropolitan Archdiocese of Puebla de los Ángeles. It was erected on 25 April 1902 as the "Diocese of Mixtecas" and renamed on 13 November 1903. It cathedra is found within the Catedral de la Virgen de Guadalupe in the episcopal see of Huajuapan de León, Oaxaca.