Dinitrobisphenol A Explained

3,3'-Dinitrobisphenol A is an organic compound with the formula (HO(O₂N)C₆H₃)₂C(CH₃)₂. It is a yellow-orange solid prepared by nitration of bisphenol A^{[1] [2]}

Carcinogenicity

It has been proposed that dinitrobisphenol A might be formed in vivo by peroxynitrite mediated oxidations of bisphenol A and that it may exhibit higher toxicity than BPA itself.^[3] 3,3'-Dinitrobisphenol A is found to be genotoxic in male ICR mice on a micronucleus test.^[4] Its estrogenic potential is not known however it has shown some binding to estrogen-related receptor gamma to an extent.^[5]

See also

• Bisphenol A
• Tetrabromobisphenol A

Notes and References

1. 10.1002/pol.1969.110070303. Synthesis and polymerization of a dinitrobisphenol a: A new polycarbonate synthesis. Journal of Polymer Science Part B: Polymer Letters. 7. 3. 185. 1969. Sulzberg. Theodore. Cotter. Robert J.. 1969JPoSL...7..185S.
2. 10.1107/S1600536811035458. 3,3′-Dinitrobisphenol A. Acta Crystallographica Section E. 67. 10. o2556. 2011. Babu. Sainath. Pathak. Chintan. Uppu. Satvika. Jones. Conrad. Fronczek. Frank R.. Uppu. Rao M.. 3201564. 22065402.
3. Masuda . Shuichi . Terashima . Yumeko . Sano . Ayako . Kuruto . Ryoko . Sugiyama . Yasumasa . Shimoi . Kayoko . Tanji . Kenichi . Yoshioka . Hisashi . Terao . Yoshiyasu . Kinae . Naohide . Changes in the mutagenic and estrogenic activities of bisphenol A upon treatment with nitrite . Mutation Research/Genetic Toxicology and Environmental Mutagenesis . August 2005 . 585 . 1-2 . 137–146 . 10.1016/j.mrgentox.2005.04.005.
4. 10.1271/bbb.80193. Genotoxicity and Estrogenic Activity of 3,3′-Dinitrobisphenol a in Goldfish. Bioscience, Biotechnology, and Biochemistry. 72. 8. 2118. 2014. Toyoizumi. Tomoyasu. Deguchi. Yuya. Masuda. Shuichi. Kinae. Naohide. free.
5. 10.1016/j.bbrc.2012.08.065. 22935422. Molecular docking of bisphenol a and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma. Biochemical and Biophysical Research Communications. 426. 2. 215. 2012. Babu. Sainath. Vellore. Nadeem A.. Kasibotla. Agasthya V.. Dwayne. Harlan J.. Stubblefield. Michael A.. Uppu. Rao M..