Metamfepramone Explained

Metamfepramone (INN, also known as dimethylcathinone, dimethylpropion, and dimepropion (BAN)) is a stimulant drug of the phenethylamine, and cathinone chemical classes. Dimethylcathinone was evaluated as an appetite suppressant and for the treatment of hypotension, but was never widely marketed.^[1]

It was used as a recreational drug in Israel under the name rakefet, but was made illegal in 2006.^[2]

Metamfepramone is metabolized to produce N-methylpseudoephedrine and methcathinone.^[3] It has also been found to be about 1.6 times less potent than methcathinone, making it roughly equipotent to cathinone itself.^[4]

Legal Status

In the United States, metamfepramone (N,N-Dimethyl-cathinone) is considered a Schedule I controlled substance as a positional isomer of mephedrone.^[5]

See also

• Dimethylamphetamine
• Substituted cathinone

Notes and References

1. Soholing WE . [Therapy of the orthostatic syndrome. Studies using dimepropion-HCI] . German . Fortschritte der Medizin . 100 . 7 . 289–293 . February 1982 . 7042502 .
2. News: Siegel-Itzkovich J . Recreational drug 'rakefet' banned . The Jerusalem Post . 22 February 2006 .
3. Thevis M, Sigmund G, Thomas A, Gougoulidis V, Rodchenkov G, Schänzer W . Doping control analysis of metamfepramone and two major metabolites using liquid chromatography-tandem mass spectrometry . European Journal of Mass Spectrometry . 15 . 4 . 507–515 . 2009 . 19661559 . 10.1255/ejms.1010 . 41715902 .
4. Dal Cason TA, Young R, Glennon RA . Cathinone: an investigation of several N-alkyl and methylenedioxy-substituted analogs . Pharmacology, Biochemistry, and Behavior . 58 . 4 . 1109–1116 . December 1997 . 9408221 . 10.1016/s0091-3057(97)00323-7 . 9704972 .
5. Web site: Orange Book - List of Controlled Substances and Regulated Chemicals . . https://web.archive.org/web/20230306093455/https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf . 6 March 2023 . live.