Dimethylallyltranstransferase Explained

Dimethylallyltranstransferase
Ec Number:	2.5.1.1
Cas Number:	9032-79-5
Width:	270

Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene and catalyzes the transformation of dimethylallylpyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) into farnesylpyrophosphate (FPP).^{[1] [2]}

Pyrophosphate is also involved, as both a reactant and a product. Geranylpyrophosphate is created in an intermediate step.

See also

• Geranyltranstransferase

Notes and References

1. Biosynthesis of geraniol and nerol in cell-free extracts of Tanacetum vulgare . Banthorpe DV, Bucknall GA, Doonan HJ, Doonan S, Rowan MG . Phytochemistry . 1976 . 15 . 1 . 91–100 . 10.1016/s0031-9422(00)89061-5. 1976PChem..15...91B .
2. Sagami H, Ogura K, Seto S, Kurokawa T . A new prenyltransferase from Micrococcus lysodeikticus . Biochemical and Biophysical Research Communications . 85 . 2 . 572–8 . November 1978 . 736921 . 10.1016/0006-291X(78)91201-9 .