Dihydroxy-acid dehydratase explained
| dihydroxy-acid dehydratase |
| Ec Number: | 4.2.1.9 |
| Cas Number: | 9024-32-2 |
| Go Code: | 0004160 |
The enzyme dihydroxy-acid dehydratase catalyzes the chemical reaction
2,3-dihydroxy-3-methylbutanoate
3-methyl-2-oxobutanoate + H
2O
This enzyme participates in valine, leucine and isoleucine biosynthesis and pantothenate and coenzyme A (CoA) biosynthesis.
Nomenclature
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming). Other names in common use include
- acetohydroxyacid dehydratase,
- α,β-dihydroxyacid dehydratase,
- 2,3-dihydroxyisovalerate dehydratase,
- α,β-dihydroxyisovalerate dehydratase,
- dihydroxy acid dehydrase,
- DHAD,
- and 2,3-dihydroxy-acid hydro-lyase.
Further reading
- Kanamori M, Wixom RL . Studies in valine biosynthesis. V. Characteristics of the purified dihydroxyacid dehydratase from spinach leaves . The Journal of Biological Chemistry . 238 . 998 - 1005 . Mar 1963 . 13962154 .
- Myers JW . Dihydroxy acid dehydrase: an enzyme involved in the biosynthesis of isoleucine and valine . The Journal of Biological Chemistry . 236 . 1414 - 8 . May 1961 . 13727223 .
