Dihydroorotase Explained

Dihydroorotase (carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines.[1] [2] It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarbamoylase. Dihydroorotase is a zinc metalloenzyme.[3]

See also

Notes and References

  1. Biosynthesis of pyrimidines . Cooper C, Wilson DW . Fed. Proc. . 1954 . 13 . 194 .
  2. Lieberman I, Kornberg A . Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin . The Journal of Biological Chemistry . 207 . 2 . 911–24 . April 1954 . 10.1016/S0021-9258(18)65708-4 . 13163076 . free .
  3. Book: Voet, Donald. Biochemistry. 2011. John Wiley & Sons. Judith G. Voet. 978-0-470-57095-1. Hoboken, NJ. 690489261.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Dihydroorotase".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.