Difluprednate Explained

Difluprednate, sold under the brand name Durezol, is a corticosteroid used for the treatment of post-operative ocular inflammation and pain.

It was approved for medical use in the United States in June 2008.^{[1] [2]} It is available as a generic medication.^[3]

Medical uses

Difluprednate is indicated for the treatment of inflammation and pain associated with ocular surgery; and the treatment of endogenous anterior uveitis.

Clinical trials

Difluprednate ophthalmic emulsion 0.05% is also being studied in other ocular inflammatory diseases, including a phase 3 study evaluating difluprednate for the treatment of anterior uveitis^[4]

Notes and References

1. Web site: Drug Approval Package: Durezol (Difluprednate) NDA #022212 . U.S. Food and Drug Administration (FDA) . 25 July 2008 . 7 March 2023.
2. Sirion Therapeutics Announces FDA Approval of Durezol for Treatment of Postoperative Ocular Inflammation and Pain . Sirion Therapeutics, Inc. . 2008-06-24 . 2008-06-30.
3. Web site: Competitive Generic Therapy Approvals . U.S. Food and Drug Administration (FDA) . 29 June 2023 . 29 June 2023 . 29 June 2023 . https://web.archive.org/web/20230629233651/https://www.fda.gov/drugs/generic-drugs/competitive-generic-therapy-approvals . live .
4. Sheppard JD, Toyos MM, Kempen JH, Kaur P, Foster CS . Difluprednate 0.05% versus prednisolone acetate 1% for endogenous anterior uveitis: a phase III, multicenter, randomized study . Investigative Ophthalmology & Visual Science . 55 . 5 . 2993–3002 . May 2014 . 24677110 . 4581692 . 10.1167/iovs.13-12660 .