Difenamizole Explained

Difenamizole (INN; brand name Pasalin; former developmental code name AP-14) is a nonsteroidal anti-inflammatory drug (NSAID) and analgesic of the pyrazolone group related to metamizole.^[1] It has monoaminergic properties, including inhibition of monoamine oxidase, augmentation of pargyline-induced elevation of striatal dopamine levels, inhibition of K⁺-induced striatal dopamine release, and inhibition of the reuptake of dopamine.^{[2] [3] [4]}

See also

• Famprofazone
• Morazone

Notes and References

1. Book: J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 398–.
2. Secci. D.. Bolasco. A.. Chimenti. P.. Carradori. S.. The State of the Art of Pyrazole Derivatives as Monoamine Oxidase Inhibitors and Antidepressant/Anticonvulsant Agents. Current Medicinal Chemistry. 18. 33. 2011. 5114–5144. 0929-8673. 10.2174/092986711797636090. 22050759.
3. Kameyama T, Nabeshima T, Yoshida N, Yamaguchi K . Neurochemical studies of an analgesic, 1,3-diphenyl-5-(2-dimethylaminopropionamide)-pyrazole [difenamizole] . Res. Commun. Chem. Pathol. Pharmacol. . 31 . 1 . 31–53 . 1981 . 6454942 .
4. NABESHIMA. Toshitaka. YAMAGUCHI. Kazumasa. KAMEYAMA. Tsutomu. Effects of Difenamizole on Content of Catecholamines and Metabolites in Mouse Brain. The Japanese Journal of Pharmacology. 28. 4. 1978. 642–646. 0021-5198. 10.1254/jjp.28.642. 732046. free.