| Type: | Bishop |
| Honorific-Prefix: | Most Reverend |
| Diego de Zambrana | |
| Archbishop-Elect of La Plata o Charcas | |
| Church: | Catholic Church |
| Archdiocese: | Archdiocese of La Plata o Charcas |
| Term: | 1608–1609 |
| Predecessor: | Luis López de Solís |
| Successor: | Alonso de Peralta |
| Death Date: | 1609 |
Diego de Zambrana (also Diego de Zambrana y Guzmán or Diego de Carmona) (died 1609) was a Roman Catholic prelate who was Archbishop Elect of La Plata o Charcas (1608–1609) and Bishop Elect of La Paz (1605–1608).[1]
On 4 July 1605, Diego de Zambrana was appointed during the papacy of Pope Paul V as the first Bishop of La Paz[2] but never arrived to take possession.[3] On 14 January 1608, he was instead appointed during the papacy of Pope Paul V as Archbishop of La Plata o Charcas. He died soon after in 1609 before he was consecrated.