| Honorific-Prefix: | Most Reverend |
| Diego de Guevara y Estrada | |
| Archbishop of Santo Domingo | |
| Church: | Catholic Church |
| Archdiocese: | Archdiocese of Santo Domingo |
| Term: | 1641–1642 |
| Predecessor: | Facundo de la Torre |
| Successor: | Maestro Valderas |
| Consecrated By: | Juan de Palafox y Mendoza |
| Birth Date: | 1612 |
| Birth Place: | México |
| Death Date: | April 1642 (age 30) |
| Death Place: | Santo Domingo |
| Nationality: | Mexican |
Diego de Guevara y Estrada (1612 - April 1642) was a Roman Catholic prelate who served as the Archbishop of Santo Domingo (1641–1642).[1]
Diego de Guevara y Estrada was born in México. On June 19, 1641, he was selected by the King of Spain and confirmed on January 13, 1642, by Pope Urban VIII as Archbishop of Santo Domingo. He was consecrated bishop by Juan de Palafox y Mendoza, Bishop of Tlaxcala with Father Nicolás de la Torre Muñoz assisting. He served as Bishop of Santo Domingo until his death in April 1642.