| Diego Osorio | |
| Fullname: | Diego Leon Osorio Rendón |
| Birth Date: | 1970 7, df=yes |
| Birth Place: | Colombia |
| Position: | Defender |
| Years1: | 1989–1990 |
| Years2: | 1991–1995 |
| Years3: | 1996 |
| Years4: | 1997–1998 |
| Clubs1: | Independiente Medellín |
| Clubs2: | Atlético Nacional |
| Clubs3: | Santa Fe |
| Clubs4: | Atlético Nacional |
| Nationalyears1: | 1991–1995 |
| Nationalteam1: | Colombia |
| Nationalcaps1: | 17 |
| Nationalgoals1: | 0 |
Diego Osorio (born 21 July 1970) is a former Colombian footballer.
Osorio began his professional career in Independiente Medellín, before moving to Atlético Nacional where he would spend most of his playing career.
Osorio made 17 appearances for the senior Colombia national football team from 1991 to 1995.[1] He also played at the 1992 Summer Olympics.[2]
Osorio also played for Colombia at the 1989 FIFA U-16 World Championship.
Osorio was arrested for cocaine possession and trafficking in Miami, Florida in August 2002.[3] Osorio was arrested for cocaine possession and trafficking in Bogota, Colombia in October 2016.