| Diogo Lopes de Sequeira | |
| Office: | Captain-major of Gold Coast |
| Term Start: | 1503? |
| Term End: | 1506? |
| Predecessor: | Fernão Lopes Correia |
| Successor: | António de Bobadilha |
| Office1: | Governor of India |
| Term Start1: | 1518 |
| Term End1: | 1522 |
| Monarch1: | Manuel I John III |
| Predecessor1: | Lopo Soares de Albergaria |
| Successor1: | Duarte de Meneses |
| Birth Date: | 1465 |
| Birth Place: | Alandroal, Kingdom of Portugal |
| Death Date: | 1530 (aged 65) |
| Death Place: | Alandroal, Kingdom of Portugal |
D. Diogo Lopes de Sequeira (1465–1530) was a Portuguese fidalgo, sent to analyze the trade potential in Madagascar and Malacca. He arrived at Malacca on 11 September 1509 and left the next year when he discovered that Sultan Mahmud Shah was planning his assassination. This gave Afonso de Albuquerque the opportunity to embark upon his expedition of conquests.
Sequeira was subsequently made governor of Portuguese India (1518–1522), and in 1520 led a military campaign into the Red Sea which hastened the first legitimate Portuguese embassy to Ethiopia.[1]