| Diego Ayala | |
| Fullname: | Diego Andres Ayala Santa Cruz |
| Birth Date: | 9 January 1990 |
| Birth Place: | Asunción, Paraguay |
| Height: | 1.77 m |
| Position: | Left back / Midfielder |
| Currentclub: | Nybergsund |
| Clubnumber: | 11 |
| Years1: | 2008–2010 |
| Clubs1: | Club Libertad |
| Caps1: | 2 |
| Goals1: | 0 |
| Years2: | 2010–2011 |
| Clubs2: | All Boys |
| Caps2: | 0 |
| Goals2: | 0 |
| Years3: | 2012 |
| Caps3: | 0 |
| Goals3: | 0 |
| Years4: | 2013– |
| Clubs4: | Nybergsund |
| Caps4: | 0 |
| Goals4: | 0 |
| Nationalyears1: | 2009 |
| Nationalteam1: | Paraguay U20 |
| Pcupdate: | 5 April 2013 |
Diego Andres Ayala Santa Cruz (born 9 January 1990) is a Paraguayan footballer who currently plays for Nybergsund.
He played for the Paraguay Under-20s in the South American Youth Championship Venezuela 2009.