Diclofenac etalhyaluronate explained

Tradename:	Joycle
Legal Status:	Rx-only in Japan
Pubchemsubstance:	348350492
Kegg:	D11020
Unii:	M88B0M598L
Synonyms:	Diclofenac etalhyaluronate sodium (JAN); SI-613

Diclofenac etalhyaluronate (INN, USAN; trade name Joycle) is an anti-inflammatory and joint function improving drug. In Japan it is approved for use in the treatment of knee osteoarthritis.^{[1] [2]}

Chemically, diclofenac etalhyaluronate consists of the drug diclofenac, a nonsteroidal antiinflammatory drug, covalently linked to hyaluronic acid.^{[3] [4]} In the body, diclofenac is slowly cleaved and released, allowing diclofenac etalhyaluronate to function as a sustained-release form of diclofenac.

Notes and References

1. Web site: Diclofenac etalhyaluronate - Seikagku Corporation . Adis Insight . Springer Nature Switzerland AG .
2. Web site: New Drug Approvals in Japan . .
3. 10.1186/s12891-019-2586-0 . Kisukeda T, Onaya J, Yoshioka K . Effect of diclofenac etalhyaluronate (SI-613) on the production of high molecular weight sodium hyaluronate in human synoviocytes . BMC Musculoskelet Disord . 20 . 201 . 2019 . 201 . 31077160 . 6511136 . free .
4. Nishida Y, Kano K, Nobuoka Y, Seo T . Efficacy and Safety of Diclofenac-Hyaluronate Conjugate (Diclofenac Etalhyaluronate) for Knee Osteoarthritis: A Randomized Phase III Trial in Japan . Arthritis & Rheumatology . Hoboken, N.J. . 73 . 9 . 1646–1655 . September 2021 . 33749997 . 8456865 . 10.1002/art.41725 . free .