Dicirenone Explained

Dicirenone (INN, USAN; developmental code name SC-26304; also known as 7α-carboxyisopropylspirolactone) is a synthetic, steroidal antimineralocorticoid of the spirolactone group which was developed as a diuretic and antihypertensive agent but was never marketed.^{[1] [2]} It was synthesized and assayed in 1974. Similarly to other spirolactones like spironolactone, dicirenone also possesses antiandrogen activity, albeit with relatively reduced affinity.^[3]

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 387–.
2. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 6 December 2012. Springer Science & Business Media. 978-94-011-4439-1. 97–.
3. Netchitailo P, Delarue C, Perroteau I, Leboulenger F, Capron MH, Vaudry H . Relative inhibitory potency of five mineralocorticoid antagonists on aldosterone biosynthesis in vitro . Biochemical Pharmacology . 34 . 2 . 189–194 . January 1985 . 2981534 . 10.1016/0006-2952(85)90123-6 .