Dichlorochromopyrrolate synthase explained

Dichlorochromopyrrolate synthase
Ec Number:	1.21.3.9

Dichlorochromopyrrolate synthase (RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3-(7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming).^{[1] [2]} This enzyme catalyses the following chemical reaction

4 2-imino-3-(7-chloroindol-3-yl)propanoate + O₂

\rightleftharpoons 2 dichlorochromopyrrolate + 2 NH₃ + 2 H₂O

This enzyme catalyses a step in the biosynthesis of rebeccamycin.

Notes and References

1. Nishizawa T, Grüschow S, Jayamaha DH, Nishizawa-Harada C, Sherman DH . Enzymatic assembly of the bis-indole core of rebeccamycin . Journal of the American Chemical Society . 128 . 3 . 724–5 . January 2006 . 16417354 . 10.1021/ja056749x .
2. Howard-Jones AR, Walsh CT . Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD . Biochemistry . 44 . 48 . 15652–63 . December 2005 . 16313168 . 10.1021/bi051706e . 10.1.1.537.5773 .