Dibutyl squarate explained

Dibutyl squarate (also known as squaric acid dibutyl ester or SADBE) is a chemical compound with the molecular formula C12H18O4. It is the dibutyl derivative of squaric acid.

Medically, it is used for the treatment of warts[1] and for treating alopecia areata or alopecia totalis (autoimmune hair loss) through topical immunotherapy involving the production of an allergic rash.[2] [3] Dibutyl squarate is currently undergoing trials for use in treating herpes labialis (cold sores).[4]

Notes and References

  1. 10.1067/mjd.2000.103631 . Squaric acid immunotherapy for warts in children . 2000 . Silverberg . Nanette B. . Lim . Joseph K. . Paller . Amy S. . Mancini . Anthony J. . Journal of the American Academy of Dermatology . 42 . 5 . 803–808 . 10775858 .
  2. 10.1016/j.autrev.2016.02.021 . Modified immunotherapy for alopecia areata . 2016 . Yoshimasu . Takashi . Furukawa . Fukumi . Autoimmunity Reviews . 15 . 7 . 664–667 . 26932732 .
  3. Haptens as drugs: contact allergens are powerful topical immunomodulators . A. M. . Holzer . L. L. . Kaplan . W. R. . Levis . J. Drugs Dermatol. . 2006 . 5 . 5 . 410–416 . 16703776.
  4. Kimball . Alexandra . 2017-05-05 . Massachusetts General Hospital . A Clinical Trial to Test the Safety and Efficacy of Squaric Acid Dibutyl Ester for the Treatment of Herpes Labialis .

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