Diapocynin Explained

Diapocynin is a dimer of apocynin.

Synthesis

Diapocynin is synthesized by the activation of apocynin with ferrous sulfate and sodium persulfate.^[1] Similar to apocynin, it is shown to have some beneficial effects against oxidative stress and reducing reactive oxygen species.^{[2] [3]}

Notes and References

1. 2008 . Synthesis of diapocynin . Journal of Chemical Education . 85 . 3. 411 . 10.1021/ed085p411 . Luchtefeld . Ron. 2008JChEd..85..411L .
2. Dranka . B. P. . Gifford . A. . Ghosh . A. . Zielonka . J. . Joseph . J. . Kanthasamy . A. G. . Kalyanaraman . B. . 2013 . Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2 R1441G) transgenic mouse . Neuroscience Letters . 549 . 57–62 . 10.1016/j.neulet.2013.05.034. 3729885 . 23721786.
3. Ismail. Hesham M.. Scapozza. Leonardo. Ruegg. Urs T.. Dorchies. Olivier M.. Diapocynin, a Dimer of the NADPH Oxidase Inhibitor Apocynin, Reduces ROS Production and Prevents Force Loss in Eccentrically Contracting Dystrophic Muscle. PLOS ONE. 17 October 2014. 9. 10. e110708. 10.1371/journal.pone.0110708. 25329652. 4201587. 2014PLoSO...9k0708I. free.