Mengla dianlovirus explained

Mengla dianlovirus (MLAV, also written Měnglà virus) is a type of filovirus identified in a Rousettus bat in Mengla County, Yunnan Province, China, and was first reported in January 2019.[1] It is classified in the same family as Ebolavirus and Marburgvirus.[2]

It is the only member of the genus Dianlovirus.[1] The name derives from Chinese: 滇, the Chinese language abbreviation for Yunnan, added to "filovirus", the common name for Filoviridae.[1] Neither the species nor the genus are listed in the 2018 ICTV classification, as the virus was formally described after that report was released. A formal proposal was submitted for the taxa in January 2019.[3]

MLAV proteins, including VP35 and VP40, inhibit host immune responses by interfering with interferon signaling, contributing to immune evasion similar to other filoviruses.[4] Like other filoviruses, Mengla virus utilizes the Niemann-Pick C1 (NPC1) receptor for cell entry, a trait that may facilitate cross-species transmission.[5]

Notes and References

  1. 10.1038/s41564-018-0328-y. 30617348. Characterization of a filovirus (Měnglà virus) from Rousettus bats in China. Nature Microbiology. 4. 3. 390–395. 2019. Yang. Xing-Lou. Tan. Chee Wah. Anderson. Danielle E.. Jiang. Ren-Di. Li. Bei. Zhang. Wei. Zhu. Yan. Lim. Xiao Fang. Zhou. Peng. Liu. Xiang-Ling. Guan. Wuxiang. Zhang. Libiao. Li. Shi-Yue. Zhang. Yun-Zhi. Wang. Lin-Fa. Shi. Zheng-Li. 57574565.
  2. Web site: New bat-borne virus related to Ebola . . January 7, 2019.
  3. Web site: Wáng . Línfā . Shí . Zhènglì . Yáng . Xìnglóu . Kuhn . Jens H. . One (1) new genus including one (1) new species in the mononegaviral family Filoviridae . International Committee on Taxonomy of Viruses (ICTV) . 25 May 2019.
  4. Williams . Caroline G. . Gibbons . Joyce Sweeney . Keiffer . Timothy R. . Luthra . Priya . Edwards . Megan R. . Basler . Christopher F. . 2019-07-01 . Impact of Měnglà virus proteins on human and bat innate immune pathways . 2024-10-31 . 10.1101/687400 .
  5. Xie . Shi-Zhe . Yao . Ke . Li . Bei . Peng . Cheng . Yang . Xing-Lou . Shi . Zheng-Li . June 2024 . Development of a Měnglà virus minigenome and comparison of its polymerase complexes with those of other filoviruses . Virologica Sinica . 39 . 3 . 459–468 . 10.1016/j.virs.2024.03.011 . 38782261 . 11279764 . 1995-820X.

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