Diaminopyrimidine Explained

Diaminopyrimidines (DAP) are a class of organic chemical compounds that include two amine groups on a pyrimidine ring.

They include many dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and piritrexim^[1] and the antibiotics Iclaprim and trimethoprim).

Some have been patented as anti-cancer drugs.^[2]

See also

• 2,4-Diaminopyrimidine
• 4,5-Diaminopyrimidine

Notes and References

1. http://aac.asm.org/cgi/content/full/45/12/3293 "Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations" Nelson et al. 2001
2. Web site: Archived copy . 2009-01-05 . https://web.archive.org/web/20110605164821/http://www.wipo.int/pctdb/en/wo.jsp?IA=GB1998000111&DISPLAY=DESC . 2011-06-05 . dead.