Diaminopimelate dehydrogenase explained

diaminopimelate dehydrogenase
Ec Number:	1.4.1.16
Cas Number:	60894-21-5
Go Code:	0047850

In enzymology, a diaminopimelate dehydrogenase is an enzyme that catalyzes the chemical reaction

meso-2,6-diaminoheptanedioate + H₂O + NADP⁺

\rightleftharpoons L-2-amino-6-oxoheptanedioate + NH₃ + NADPH + H⁺

The 3 substrates of this enzyme are meso-2,6-diaminoheptanedioate, H₂O, and NADP⁺, whereas its 4 products are L-2-amino-6-oxoheptanedioate, NH₃, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating). Other names in common use include meso-alpha,epsilon-diaminopimelate dehydrogenase, and meso-diaminopimelate dehydrogenase. This enzyme participates in lysine biosynthesis.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and .

References

• Misono H, Togawa H, Yamamoto T, Soda K . 1976 . Occurrence of meso-alpha, epsilon-diaminopimelate dehydrogenase in Bacillus sphaericus . Biochem. Biophys. Res. Commun. . 72 . 89 - 93 . 10904 . 1 . 10.1016/0006-291X(76)90964-5.
• Misono H, Togawa H, Yamamoto T, Soda K . 1979 . Meso-alpha,epsilon-diaminopimelate D-dehydrogenase: distribution and the reaction product . J. Bacteriol. . 137 . 22 - 7 . 762012 . 1 . 10.1128/JB.137.1.22-27.1979 . 218413 .