Diacylglycerol diphosphate phosphatase explained

Diacylglycerol diphosphate phosphatase
Ec Number:	3.1.3.81

Diacylglycerol diphosphate phosphatase (DGPP phosphatase, DGPP phosphohydrolase, DPP1, DPPL1, DPPL2, PAP2, pyrophosphate phosphatase) is an enzyme with systematic name 1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase.^{[1] [2] [3] [4] [5] [6]} This enzyme catalyses the following chemical reaction

1,2-diacyl-sn-glycerol 3-diphosphate + H₂O

\rightleftharpoons 1,2-diacyl-sn-glycerol 3-phosphate + phosphate

The phosphatase activity of this enzyme is Mg²⁺-independent.

Notes and References

1. Dillon DA, Wu WI, Riedel B, Wissing JB, Dowhan W, Carman GM . The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity . The Journal of Biological Chemistry . 271 . 48 . 30548–53 . November 1996 . 8940025 . 10.1074/jbc.271.48.30548 . free .
2. Dillon DA, Chen X, Zeimetz GM, Wu WI, Waggoner DW, Dewald J, Brindley DN, Carman GM . Mammalian Mg2+-independent phosphatidate phosphatase (PAP2) displays diacylglycerol pyrophosphate phosphatase activity . The Journal of Biological Chemistry . 272 . 16 . 10361–6 . April 1997 . 9099673 . 10.1074/jbc.272.16.10361 . free.
3. Wu WI, Liu Y, Riedel B, Wissing JB, Fischl AS, Carman GM . Purification and characterization of diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae . The Journal of Biological Chemistry . 271 . 4 . 1868–76 . January 1996 . 8567632 . 10.1074/jbc.271.4.1868 . free .
4. Oshiro J, Han GS, Carman GM . Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae . Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids . 1635 . 1 . 1–9 . November 2003 . 14642771 . 10.1016/j.bbalip.2003.10.002 .
5. Carman GM . Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli . Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism . 1348 . 1–2 . 45–55 . September 1997 . 9370315 . 10.1016/s0005-2760(97)00095-7 .
6. Han GS, Johnston CN, Chen X, Athenstaedt K, Daum G, Carman GM . Regulation of the Saccharomyces cerevisiae DPP1-encoded diacylglycerol pyrophosphate phosphatase by zinc . The Journal of Biological Chemistry . 276 . 13 . 10126–33 . March 2001 . 11139591 . 10.1074/jbc.m011421200 . free .