Dhevalapally B. Ramachary Explained

Dhevalapally B. Ramachary
Birth Place:Thatikal, Nalgonda, India
Nationality:Indian
Field:Chemistry
Workplaces:University of Hyderabad
Alma Mater:University of Hyderabad
Indian Institute of Science
The Scripps Research Institute
Thesis Title:Total synthesis of Sesquiterpenes containing three contiguous quarternary carbon atoms
Thesis Year:2001
Doctoral Advisor:Prof. Adusumilli Srikrishna
Known For:Organic Chemistry, Organocatalysis, Supramolecular-organocatalysis, Asymmetric Catalysis, Click chemistry

Dhevalapally B. Ramachary FTAS, FRSC, FASc, FNASc, also known as D. B. Ramachary (born 1973), is an Indian chemist and professor at the School of Chemistry, University of Hyderabad. He has made numerous contributions in various fields of chemical science.

Early life and education

D. B. Ramachary was born to Shri Ramalingaiahchary and Ramalingamma in 1973, at Thatikal village, Nakrekal mandal, Nalgonda district of Telangana. He did his early schooling at ZPHS schools at Thatikal and Nakrekal, and later joined for an under graduate BSc programme at Nagarjuna Government College (Autonomous) at Nalgonda (1991–1994). Later, he moved to School of Chemistry, University of Hyderabad for pursuing MSc chemistry (1994–96), and then he obtained a PhD in synthetic organic chemistry under the guidance of Prof. A. Srikrishna at Indian Institute of Science in 1996–2001 for the total synthesis of sesquiterpenes.[1] [2]

Soon after his PhD in 2001, he moved to US as a Skaggs Postdoctoral Fellow and worked with Carlos F. Barbas III at Department of Chemistry and Molecular Biology, The Scripps Research Institute in La Jolla, United States during 2002–2005 for the development of small molecular-catalysis.[3] [4] [5] [6] [7]

Academic career

Ramachary was lecturer (2005–2007), reader (2007–2010), associate professor (2010–2013), and at present he is a full professor of organic chemistry since 2013 at the Catalysis laboratory, School of Chemistry, University of Hyderabad. He has authored more than 100 research papers.[8]

Research

In 2005, when Ramachary started his own research career at School of Chemistry, UoH, he showed interest towards discovering green reactions and catalysts. His laboratory mainly focused on the development of organocatalytic sequential one-pot reactions, asymmetric supramolecular catalysis and organocatalysis, development of multi-component and multi-catalysis cascade reactions,[9] and metal-free carbonyls based click chemistry.[10] [11] [12]

His laboratory discovered important reactions based on three-component reductive alkylation (TCRA)[13] [14] [15] [16] and push-pull dienamine (PPD) reactions.[17] [18] [19] [20] His research also focuses on the theoretical aspects of organocatalysis in finding out the suitable organocatalyst for stereoselective reactions using computational resources which helps in achieving better synthetic methodologies. Using this, his research group observed the electrostatic and dipole-dipole interactions in proline-catalyzed asymmetric desymmetrization of pro-chiral ketones with nitrosobenzene.[21] He has also examined the trapping or stabilizing of king size pre- or post-transition states of asymmetric reactions by designing new tool ‘asymmetric supramolecular catalysis’ through which characterization of large-size supramolecular rings in the pre-transition state (pre-TS) of enol- or enamine-based Michael reactions for high asymmetric induction was reported.[22] [23] His contributions through original developed reactions were used by organic, medicinal, material chemists and these reactions became well-known organic reactions to be named after him. The reactions which are named after him are: 1) Ramachary Reductive Coupling Reaction,[24] 2) Ramachary-Bressy-Wang Cycloaddition,[25] 3) Ramachary Aminoenyne-catalysis,[26] [27] [28] [29] 4) Ramachary Base Induced Ring Opening (BIRO) Reaction,[30] [31] 5) Ramachary Azide-Carbonyl [3+2]-Cycloaddition.[32] [33] [34]

Awards and honors

External links

Notes and References

  1. Srikrishna . A.. Ramachary. D. B.. 1999-09-03. First total synthesis of (±)-β-microbiotene, (±)-microbiotol and (±)-cyclocuparenol. Tetrahedron Letters. 40. 36. 6669–6670. 0040-4039. 10.1016/S0040-4039(99)01342-8.
  2. 10.1002/chin.200738174. Total Synthesis of (±)-β-Microbiotene (I), (±)-Microbiotol (II), (±)-Cyclocuparanol (III) and (±)-β-Cuparenones (IV). 2007. Srikrishna. A.. Ramachary. D. B.. ChemInform. 38. 38.
  3. Ramachary. D. B.. Barbas. Carlos F.. 2005-03-17. Direct Amino Acid-Catalyzed Asymmetric Desymmetrization of meso-Compounds: Tandem Aminoxylation/O−N Bond Heterolysis Reactions. Organic Letters. 7. 8. 1557–1580. 10.1021/ol050246e. 15816756.
  4. Suri . Jeff T.. Ramachary . D. B.. Barbas. Carlos F.. 2005-03-01. Mimicking Dihydroxy Acetone Phosphate-Utilizing Aldolases through Organocatalysis: A Facile Route to Carbohydrates and Aminosugars. Organic Letters. 7. 7. 1383–1385. 10.1021/ol0502533. 15787512.
  5. Ramachary. D. B.. Anebouselvy . K.. Chowdari. Naidu S.. Barbas. Carlos F.. 2004-08-06. Direct Organocatalytic Asymmetric Heterodomino Reactions: The Knoevenagel/Diels−Alder/Epimerization Sequence for the Highly Diastereoselective Synthesis of Symmetrical and Nonsymmetrical Synthons of Benzoannelated Centropolyquinanes. The Journal of Organic Chemistry. 69. 18. 5838–5849. 10.1021/jo049581r. 15373469.
  6. Ramachary . D. B.. Chowdari. Naidu S.. Barbas. Carlos F.. 2003-09-15. Organocatalytic Asymmetric Domino Knoevenagel/Diels–Alder Reactions: A Bioorganic Approach to the Diastereospecific and Enantioselective Construction of Highly Substituted Spiro[5,5]undecane‐1,5,9‐triones. Angewandte Chemie. 115. 35. 4365–4369. 10.1002/ange.200351916. 2003AngCh.115.4365R.
  7. Chowdari. Naidu S.. Ramachary. D. B.. Barbas. Carlos F.. 2003-04-22. Organocatalytic Asymmetric Assembly Reactions: One-Pot Synthesis of Functionalized β-Amino Alcohols from Aldehydes, Ketones, and Azodicarboxylates. Organic Letters. 5. 10. 1685–1688. 10.1021/ol034333n. 12735752.
  8. Prof. D. B. Ramachary Research Laboratory Homepage, http://chemistry.uohyd.ac.in/~dbr/index.htm
  9. Ramachary. D. B.. Sangeeta Jain. 2010-12-01. Sequential one-pot combination of multi-component and multi-catalysis cascade reactions: an emerging technology in organic synthesis. Organic & Biomolecular Chemistry. 9. 5. 1277–1300. 10.1039/C0OB00611D. 21120241.
  10. Ramachary. D. B.. Kishor. Mamillapalli. Vijayendar Reddy. Y.. 2008-02-06. Development of Pharmaceutical Drugs, Drug Intermediates and Ingredients by Using Direct Organo‐Click Reactions. European Journal of Organic Chemistry. 2008. 6. 975–993. 10.1002/ejoc.200701014.
  11. Ramachary. D. B.. Rumpa Mondal. Venkaiah. Chintalapudi. 2010-05-28. Rapid Synthesis of Functionalized Indenes, Triazoles, and Glucocorticoid Receptor Modulators by Sequential Multicatalysis Cascade Reactions. European Journal of Organic Chemistry. 2010. 17. 3205–3210. 10.1002/ejoc.201000220.
  12. Ramachary. D. B.. Shaahank. Adluri B.. Karthik. S.. 2014-07-30. An Organocatalytic Azide–Aldehyde [3+2] Cycloaddition: High‐Yielding Regioselective Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles. Angewandte Chemie International Edition. 53. 39. 10420–10424. 10.1002/anie.201406721. 25079606.
  13. Ramachary. D. B.. Kishor. Mamillapalli. 2008-08-12. Direct amino acid-catalyzed cascade biomimetic reductive alkylations: application to the asymmetric synthesis of Hajos–Parrish ketone analogues. Organic & Biomolecular Chemistry. 6. 22. 4176–4187. 10.1039/B807999D. 18972048.
  14. Ramachary. D. B.. Vijayendar Reddy . Y.. 2009-12-02. A General Approach to Chiral Building Blocks via Direct Amino Acid-Catalyzed Cascade Three-Component Reductive Alkylations: Formal Total Synthesis of HIV-1 Protease Inhibitors, Antibiotic Agglomerins, Brefeldin A, and (R)-γ-Hexanolide. The Journal of Organic Chemistry. 75. 1. 74–85. 10.1021/jo901799n. 19954143.
  15. Ramachary. D. B.. Kishor. Mamillapalli. 2010-05-07. Direct catalytic asymmetric synthesis of highly functionalized tetronic acids/tetrahydro-isobenzofuran-1,5-diones via combination of cascade three-component reductive alkylations and Michael-aldol reactions. Organic & Biomolecular Chemistry. 8. 12. 2859–2867. 10.1039/C003588B. 20454721.
  16. Ramachary. D. B.. Anif Pasha. Mohammed B.. Thirupathi. Guguloth. 2017-08-07. Organocatalytic Asymmetric Formal [3+2] Cycloaddition as a Versatile Platform to Access Methanobenzo[7]annulenes. Angewandte Chemie International Edition. 56. 42. 12930–12934. 10.1002/anie.201706557. 28783234.
  17. Ramachary. D. B.. Ramakumar . Kinthada. Narayana. Vidadala V. F.. 2007-01-20. Organocatalytic Cascade Reactions Based on Push−Pull Dienamine Platform: Synthesis of Highly Substituted Anilines. The Journal of Organic Chemistry. 72. 4. 1458–1463. 10.1021/jo0623639. 17288390.
  18. Ramachary. D. B.. Ramakumar . Kinthada. Narayana. Vidadala V. F.. 2008-10-10. Amino Acid‐Catalyzed Cascade [3+2]‐Cycloaddition/Hydrolysis Reactions Based on the Push–Pull Dienamine Platform: Synthesis of Highly Functionalized NH‐1,2,3‐Triazoles. Chemistry – A European Journal. 14. 30. 9143–9147. 10.1002/chem.200801325. 18767077.
  19. Ramachary. D. B.. Ramakumar . Kinthada. 2011-03-09. Direct Organocatalytic Asymmetric Approach to Baylis–Hillman‐Type Products Through a Push–Pull Dienamine Platform. European Journal of Organic Chemistry. 2011. 14. 2599–2605. 10.1002/ejoc.201100075.
  20. Ramachary. D. B.. Vijayendar Reddy. V.. 2011-11-08. Dienamine Catalysis: An Emerging Technology in Organic Synthesis. European Journal of Organic Chemistry. 2012. 5. 865–887. 10.1002/ejoc.201101157.
  21. Joseph. Jorly. Ramachary. D. B.. Jemmis. Eluvathingal D.. 2006-06-21. Electrostatic repulsion as an additional selectivity factor in asymmetric proline catalysis. Organic & Biomolecular Chemistry. 4. 14. 2685–2689. 10.1039/B606996G. 16826292.
  22. Ramachary. D. B.. Madhavachary. R. B.. ShivaPrasad. M.. 2012-02-10. Observation of neighboring ortho-hydroxyl group participation in organocatalytic asymmetric sequential Michael-lactonization reactions: synthesis of highly substituted chiral spirodihydrocoumarins. Organic & Biomolecular Chemistry. 10. 30. 5825–5829. 10.1039/C2OB07122C. 22391626.
  23. Ramachary. D. B.. Sakthidevi. Rajasekar B.. Shruthi. Kodambahalli S.. 2012-05-30. Asymmetric Supramolecular Catalysis: A Bio‐Inspired Tool for the High Asymmetric Induction in the Enamine‐Based Michael Reactions. Chemistry – A European Journal. 18. 26. 8008–8012. 10.1002/chem.201200962. 22649025.
  24. Jiang. G.. Liu. M.. Fang. D.. Tan. P.. Huang. M.. Zhou. T.. Jiang. Z.. Xu. Z.. Wang. Z.. 2018-02-28. A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates. RSC Advances. 8. 16. 8961–8964. 10.1039/C8RA00326B. 2018RSCAd...8.8961J. free. 10072/384561. free.
  25. Sangwan. R. B.. Javed. Dubey. A.. Mandal. P. K.. 2017-06-13. Organocatalytic [3+2] Cycloadditions: Toward Facile Synthesis of Sulfonyl‐1,2,3‐Triazolyl and Fully Substituted 1,2,3‐Triazolyl Glycoconjugates. ChemistrySelect. 2. 17. 4733–4743. 10.1002/slct.201700805.
  26. Aleman. J. . Cabrera. S.. 2012-11-15. Applications of asymmetric organocatalysis in medicinal chemistry . Chemical Society Reviews. 42. 2. 774–793. 10.1039/C2CS35380F. 23154582 .
  27. Fraile. A. . Parra. A.. Tortosa. M.. Aleman. J.. 2014-12-02. Organocatalytic transformations of alkynals, alkynones, propriolates, and related electron-deficient alkynes. Tetrahedron. 70. 48. 9145–9173. 10.1016/j.tet.2014.07.023.
  28. Peng. S. . Wang. Z.. Zhang. L.. Zhang. X.. Huang. Y.. 2018-01-25. Streamlined asymmetric α-difunctionalization of ynones.. Nature Communications. 9. 1. 375. 10.1038/s41467-017-02801-9. 29371601 . 5785506 . 2018NatCo...9..375P . free.
  29. Liu. W. . Zou. L.. Fu. B.. Wang. X.. Wang. K.. Sun. Z. . Peng. F.. Wang. W.. Shao. Z.. 2016-08-29. Michael Donors in Chemo-, Enantio-, and γ-Selective 1,4-Conjugate Additions with Nitroolefins. The Journal of Organic Chemistry. 81. 18. 8296–8305. 10.1021/acs.joc.6b01425. 27571411 .
  30. Schmidt. B. . Kunz. O.. 2011-12-16. One‐Flask Tethered Ring Closing Metathesis–Electrocyclic Ring Opening for the Highly Stereoselective Synthesis of Conjugated Z/E‐Dienes . European Journal of Organic Chemistry. 2012. 5. 1008–1018. 10.1002/ejoc.201101497.
  31. Schmidt. B. . Kunz. O.. 2013-08-14. Stereoselective Synthesis of Dienyl Phosphonates via Extended Tethered Ring-Closing Metathesis. Organic Letters. 15. 17. 4470–4473. 10.1021/ol4020078. 23944227 .
  32. Web site: 2019-11-07 . Breakthrough findings by University of Hyderabad professor . 2023-07-28 . www.thehansindia.com . en.
  33. Web site: 2019-11-06 . Indian chemist has key chemical reactions named after him . 2023-07-28 . www.thehindubusinessline.com . en.
  34. Web site: Reaxys - An expert-curated chemistry database . 2023-07-28 . www.elsevier.com.
  35. Web site: Finding a green reaction for drugs: Why this UoH prof got invited to the Royal Society of Chemistry . 2023-07-28 . Edex Live . en.
  36. Highlighted in News, Telangana Today, https://telanganatoday.com/honour-for-uoh-faculty-2
    • Fellow - Indian Academy of Sciences, https://www.ias.ac.inpdescribe/fellow/Ramachary,_Prof._Dhevalapally_B
  38. https://www.tasc.org.in/newly-elected-fellows.htm
  39. Ramachary. D. B.. CRSI Bronze Medals: P. S. Mukherjee, D. B. Ramachary, T. Govindaraju, and R. Gupta / SwarnaJayanti Fellowships: S. Ghosh and C. M. Reddy / Albrecht Kossel Prize: J. Buchner / DECHEMA Early‐Career Researcher Prize: T. A. M. Gulder / Mattauch–Herzog Prize: K. Pagel / Honorary Doctorates: F. Schüth and T. J. Marks / Karl Max von Bauernfeind Medal: C. W. Kohlpaintner. Angewandte Chemie International Edition. 2016. 55. 27. 7578–7579. 10.1002/anie.201604544. 27254753.
  40. Previous Recipients of the BM Birla Science Prizes, https://www.birlasciencecentre.org/awards/previous-receipients-of-the-bm-birla-science-prizes/
  41. Previous Recipients of Anil Kumar Bose Memorial Award, http://insaindia.res.in/youngmedal.php
  42. Previous Recipients of Indian National Science Academy Medal for Young Scientist 2006, http://insaindia.res.in/youngmedal.php
  43. Ramachary. D. B.. Author profile. European Journal of Organic Chemistry. 2018. 16. 1834. 10.1002/ejoc.201800182.

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