DGKQ explained

Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.^{[1] [2] [3]}

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.

Interactions

DGKQ has been shown to interact with RHOA.^[4]

Further reading

• Sakane F, Kanoh H . Molecules in focus: diacylglycerol kinase . Int. J. Biochem. Cell Biol. . 29 . 10 . 1139–43 . 1998 . 9438377 . 10.1016/S1357-2725(97)00037-X.
• Li D . Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17 . Mol. Cell. Biol. . 27 . 19 . 6669–85 . 2008 . 17664281 . 10.1128/MCB.00355-07 . 2099220 . vanc. Urs AN . Allegood J . 3 . Leon . A. . Merrill . A. H. . Sewer . M. B. .
• van Baal J, de Widt J, Divecha N, van Blitterswijk WJ . Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C . J. Biol. Chem. . 280 . 11 . 9870–8 . 2005 . 15632189 . 10.1074/jbc.M409301200 . free .
• Tabellini G . Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus . Exp. Cell Res. . 287 . 1 . 143–54 . 2003 . 12799190 . 10.1016/S0014-4827(03)00115-0 . vanc. Bortul R . Santi S . 3 . Riccio . Massimo . Baldini . Giovanna . Cappellini . Alessandra . Billi . Anna Maria . Berezney . Ronald . Ruggeri . Alessandra .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Houssa B . Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA . J. Biol. Chem. . 274 . 11 . 6820–2 . 1999 . 10066731 . 10.1074/jbc.274.11.6820 . vanc. de Widt J . Kranenburg O . 3 . Moolenaar . WH . Van Blitterswijk . WJ . free.
• Sakane F . Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases . J. Biol. Chem. . 271 . 14 . 8394–401 . 1996 . 8626538 . 10.1074/jbc.271.14.8394 . vanc. Imai S . Kai M . 3 . Wada . I . Kanoh . H . free.

Notes and References

1. Endele S, Zabel B, Winterpacht A . Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3 . Genomics . 33 . 1 . 145–6 . Jun 1996 . 8617502 . 10.1006/geno.1996.0174 .
2. Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ . Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain . J Biol Chem . 272 . 16 . 10422–8 . May 1997 . 9099683 . 10.1074/jbc.272.16.10422 . free .
3. Web site: Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa.
4. Houssa . B . de Widt J . Kranenburg O . Moolenaar W H . van Blitterswijk W J . Mar 1999 . Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA . J. Biol. Chem. . 274 . 11 . 6820–2 . 0021-9258. 10066731 . 10.1074/jbc.274.11.6820 . free .