Deucravacitinib Explained
Pronounce: |
|
Tradename: | Sotyktu |
Dailymedid: | Deucravacitinib |
Pregnancy Au: | B1 |
Pregnancy Au Comment: | [1] |
Routes Of Administration: | By mouth |
Atc Prefix: | L04 |
Atc Suffix: | AF07 |
Class: | Tyrosine kinase 2 (TYK2) inhibitor |
Legal Au: | S4 |
Legal Au Comment: | [2] |
Legal Ca: | Rx-only |
Legal Ca Comment: | [3] [4] [5] |
Legal Uk: | POM |
Legal Uk Comment: | [6] |
Legal Us: | Rx-only |
Legal Us Comment: | [7] |
Legal Eu: | Rx-only |
Legal Eu Comment: | [8] [9] |
Bioavailability: | 99% |
Protein Bound: | 82–90% |
Metabolism: | Liver (primarily CYP1A2) |
Metabolites: | BMT-153261 (active) |
Elimination Half-Life: | 10 hours |
Excretion: | Feces, urine |
Cas Number: | 1609392-27-9 |
Pubchem: | 134821691 |
Drugbank: | DB16650 |
Chemspiderid: | 72380005 |
Unii: | N0A21N6RAU |
Kegg: | D11817 |
Chembl: | 435170 |
Synonyms: | BMS-986165 |
Iupac Name: | 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)phenyl)amino)-N-(trideuteromethyl)pyridazine-3-carboxamide |
C: | 20 |
H: | 19 |
D: | 3 |
N: | 8 |
O: | 3 |
Smiles: | [2H]C([2H])([2H])NC(=O)C1=NN=C(C=C1NC2=CC=CC(=C2OC)C3=NN(C=N3)C)NC(=O)C4CC4 |
Stdinchi: | 1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4-5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23,24,25,29)/i1D3 |
Stdinchikey: | BZZKEPGENYLQSC-FIBGUPNXSA-N |
Deucravacitinib, sold under the brand name Sotyktu, is a medication used for the treatment of moderate-to-severe plaque psoriasis. It is a tyrosine kinase 2 (TYK2) inhibitor and it is taken by mouth. It was developed by Bristol Myers Squibb.[10]
Deucravacitinib was approved for medical use in the United States in September 2022,[11] [12] and in Australia in December 2022. The US Food and Drug Administration (FDA) considers it to be a first-in-class medication.[13] [14]
Medical uses
Deucravacitinib is indicated for the treatment of adults with moderate-to-severe plaque psoriasis.
Mechanism of action
It acts as a highly selective allosteric inhibitor of non-receptor tyrosine-protein kinase 2 (TYK2).[15]
Molecule design
The chemical structure of deucravacitinib contains a methyl amide in which all three hydrogen atoms are replaced by deuterium.[16]
Society and culture
Legal status
In January 2023, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Sotyktu, intended for the treatment of moderate to severe psoriasis. The applicant for this medicinal product is Bristol-Myers Squibb Pharma EEIG.[17] Deucravacitinib was approved for medical use in the European Union in March 2023.
Notes and References
- Web site: Sotyktu . Therapeutic Goods Administration (TGA) . 14 December 2022 . 15 April 2023 . 9 June 2023 . https://web.archive.org/web/20230609012234/https://www.tga.gov.au/resources/auspmd/sotyktu . live .
- Web site: Sotyktu (Bristol-Myers Squibb Australia Pty Ltd) . Therapeutic Goods Administration (TGA) . 13 January 2023 . 9 April 2023 . 27 March 2023 . https://web.archive.org/web/20230327062418/https://www.tga.gov.au/resources/prescription-medicines-registrations/sotyktu-bristol-myers-squibb-australia-pty-ltd . live .
- Web site: Details for: Sotyktu . . 14 February 2023 . 3 March 2024 . 3 March 2024 . https://web.archive.org/web/20240303052906/https://dhpp.hpfb-dgpsa.ca/dhpp/resource/102205 . live .
- Web site: Notice: Multiple Additions to the Prescription Drug List (PDL) [2023-03-08] ]. . 8 March 2023 . 21 March 2023 . 22 March 2023 . https://web.archive.org/web/20230322024545/https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/prescription-drug-list/notices-changes/mutliple-additions-2023-03-08.html . live .
- Web site: Summary Basis of Decision - Sotyktu . . 10 March 2023 . 24 April 2023 . 25 April 2023 . https://web.archive.org/web/20230425001504/https://hpr-rps.hres.ca/reg-content/summary-basis-decision-detailTwo.php?linkID=SBD00628&lang=en . live .
- Web site: Sotyktu Summary of Product Characteristics (SmPC) . (emc) . 13 July 2023 . 20 December 2023 . 20 December 2023 . https://web.archive.org/web/20231220061538/https://www.medicines.org.uk/emc/product/14871/smpc . live .
- Web site: Sotyktu- deucravacitinib tablet, film coated . DailyMed . 9 September 2022 . 27 September 2022 . 28 September 2022 . https://web.archive.org/web/20220928042407/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ff4d7258-5068-4cdf-9692-8cae04c3198e . live .
- Web site: Sotyktu EPAR . European Medicines Agency (EMA) . 24 March 2023 . 3 March 2024 . 19 February 2024 . https://web.archive.org/web/20240219214724/https://www.ema.europa.eu/en/medicines/human/EPAR/sotyktu . live .
- Web site: Sotyktu . Union Register of medicinal products . 27 March 2023 . 30 March 2023 . 31 March 2023 . https://web.archive.org/web/20230331060619/https://ec.europa.eu/health/documents/community-register/html/h1718.htm . live .
- U.S. Food and Drug Administration Approves Sotyktu (deucravacitinib), Oral Treatment for Adults with Moderate-to-Severe Plaque Psoriasis . Bristol Myers Squibb . Business Wire . 10 September 2022 . 10 September 2022 . 10 September 2022 . https://web.archive.org/web/20220910143525/https://www.businesswire.com/news/home/20220817005643/en/ . live .
- Web site: Drug Approval Package: Sotyktu . U.S. Food and Drug Administration (FDA) . 14 October 2022 . 4 January 2023 . 5 January 2023 . https://web.archive.org/web/20230105034534/https://www.accessdata.fda.gov/drugsatfda_docs/nda/2022/214958Orig1s000TOC.cfm . live .
- Truong TM, Pathak GN, Singal A, Taranto V, Rao BK . Deucravacitinib: The First FDA-Approved Oral TYK2 Inhibitor for Moderate to Severe Plaque Psoriasis . The Annals of Pharmacotherapy . 58. 4. 416–427 . June 2023 . 37341177 . 10.1177/10600280231153863 . 259211735 .
- Web site: Advancing Health Through Innovation: New Drug Therapy Approvals 2022 . U.S. Food and Drug Administration (FDA) . 10 January 2023 . 22 January 2023 . 21 January 2023 . https://web.archive.org/web/20230121035714/https://www.fda.gov/drugs/new-drugs-fda-cders-new-molecular-entities-and-new-therapeutic-biological-products/new-drug-therapy-approvals-2022 . live .
- New Drug Therapy Approvals 2022 . U.S. Food and Drug Administration (FDA) . January 2024 . PDF . 14 January 2024 . https://web.archive.org/web/20240114065648/https://www.fda.gov/media/164429/download . 14 January 2024 . live .
- Chimalakonda A, Burke J, Cheng L, Catlett I, Tagen M, Zhao Q, Patel A, Shen J, Girgis IG, Banerjee S, Throup J . Selectivity Profile of the Tyrosine Kinase 2 Inhibitor Deucravacitinib Compared with Janus Kinase 1/2/3 Inhibitors . Dermatology and Therapy . 11 . 5 . 1763–1776 . October 2021 . 34471993 . 10.1007/s13555-021-00596-8 . 8484413 .
- Mullard A . First de novo deuterated drug poised for approval . Nature Reviews. Drug Discovery . 21 . 9 . 623–625 . September 2022 . 35974147 . 10.1038/d41573-022-00139-6 . 251623586 .
- Web site: Sotyktu: Pending EC decision . European Medicines Agency (EMA) . 26 January 2023 . 28 January 2023 . 27 January 2023 . https://web.archive.org/web/20230127225406/https://www.ema.europa.eu/en/medicines/human/summaries-opinion/sotyktu . dead .