| Despotis | |
| Name Local: | Δεσπότης |
| Periph: | West Macedonia |
| Periphunit: | Grevena |
| Municunit: | Grevena |
| Community: | Agioi Theodoroi |
| Population: | 13 |
| Population As Of: | 2021 |
| Coordinates: | 40.0117°N 46.8°W |
| Postal Code: | 511 00 |
| Area Code: | +30-2462 |
| Licence: | PN |
| Elevation: | 670 |
Despotis is a village of the Grevena municipality. Before the 1997 local government reform it was a part of the community of Agioi Theodoroi.[1] The 2021 census recorded 13 residents in the village.