Desocodeine Explained

Desocodeine is a potent semi-synthetic opioid which is the penultimate intermediate in the manufacture of desomorphine from codeine.[1] [2] Desocodeine is a potent analgesic, being as potent as morphine.It is partially metabolized into desomorphine, among others, after parenteral and oral administration.[3] [4]

Since 1936, desocodeine has been classified in the US as a Schedule I controlled substance under the Controlled Substances Act, indicating that the FDA has determined that there are no legal medicinal uses for it.[5]

In Canada, desocodeine is classified as a Schedule I drug under the Controlled Drugs and Substances Act.

Notes and References

  1. Web site: PubChem . Desocodeine . 2022-11-15 . pubchem.ncbi.nlm.nih.gov . en.
  2. Web site: Desocodeine C18H23NO2 ChemSpider . 2022-11-15 . www.chemspider.com.
  3. Eddy NB . 1 November 1935 . STUDIES OF MORPHINE, CODEINE AND THEIR DERIVATIVES X. DESOXYMORPHINE-C, DESOXYCODEINE-C AND THEIR HYDROGENATED DERIVATIVES . Journal of Pharmacology and Experimental Therapeutics . 55 . 1 . 257–267 . 93217792 .
  4. Himmelsbach Clifton K. 1939. STUDIES OF CERTAIN ADDICTION CHARACTERISTICS OF (a) DIHYDROMORPHINE ("PARAMORPHAN"), (b) DIHYDRODESOXYMORPHINE-D ("DESOMORPHINE"), (c) DIHYDRODESOXYCODEINE-D ("DESOCODEINE"), AND (d) METHYLDIHYDROMORPHINONE ("METOPON"). Journal of Pharmacology and Experimental Therapeutics. 1939. 67. 239–249. 102042333 .
  5. Web site: DEA Diversion Control Division . 4 May 2015 . 4 March 2016 . https://web.archive.org/web/20160304053357/http://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm . dead .

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