Desmoglein-4 Explained

Desmoglein-4 is a protein that in humans is encoded by the DSG4 gene.^{[1] [2]}

See also

• List of conditions caused by problems with junctional proteins

Further reading

• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Kljuic A . Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris . Cell . 113 . 2 . 249–60 . 2003 . 12705872 . 10.1016/S0092-8674(03)00273-3 . vanc. Bazzi H . Sundberg JP . 3 . Martinez-Mir . Amalia . O'Shaughnessy . Ryan . Mahoney . My G . Levy . Moise . Montagutelli . Xavier . Ahmad . Wasim . 15131587 . free .
• Rafiq MA . A recurrent intragenic deletion mutation in DSG4 gene in three Pakistani families with autosomal recessive hypotrichosis . J. Invest. Dermatol. . 123 . 1 . 247–8 . 2004 . 15191570 . 10.1111/j.0022-202X.2004.22715.x . vanc. Ansar M . Mahmood S . 3 . Haque . Sayedul . Faiyaz-Ul-Haque . Muhammad . Leal . Suzanne M. . Ahmad . Wasim . 6157275 . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Nagasaka T . Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome . J. Clin. Invest. . 114 . 10 . 1484–92 . 2004 . 15545999 . 10.1172/JCI20480 . 525737 . vanc. Nishifuji K . Ota T . 3 . Whittock . NV . Amagai . M .
• Bazzi H, Martinez-Mir A, Kljuic A, Christiano AM . Desmoglein 4 mutations underlie localized autosomal recessive hypotrichosis in humans, mice, and rats . Journal of Investigative Dermatology Symposium Proceedings . 10 . 3 . 222–4 . 2006 . 16382669 . 10.1111/j.1087-0024.2005.10110.x . free .
• Bazzi H . Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle . Differentiation . 74 . 2–3 . 129–40 . 2006 . 16533311 . 10.1111/j.1432-0436.2006.00061.x . vanc. Getz A . Mahoney MG . 3 . Ishida-Yamamoto . Akemi . Langbein . Lutz . Wahl . James K. . Christiano . Angela M. .
• Wajid M . Localized autosomal recessive hypotrichosis due to a frameshift mutation in the desmoglein 4 gene exhibits extensive phenotypic variability within a Pakistani family . J. Invest. Dermatol. . 127 . 7 . 1779–82 . 2007 . 17392831 . 10.1038/sj.jid.5700791 . vanc. Bazzi H . Rockey J . 3 . Lubetkin . Jillian . Zlotogorski . Abraham . Christiano . Angela M . free.

Notes and References

1. Whittock NV, Bower C . Genetic evidence for a novel human desmosomal cadherin, desmoglein 4 . J Invest Dermatol . 120 . 4 . 523–30 . Mar 2003 . 12648213 . 10.1046/j.1523-1747.2003.12113.x . free .
2. Web site: Entrez Gene: DSG4 desmoglein 4.