Desmethoxyfallypride Explained

Drug Name:

Desmethoxyfallypride (¹⁸F)

Width:

240

Atc Prefix:

none

Cas Number:

166173-81-5

Pubchem:

10404663

Chemspiderid:

8580101

Unii:

CJD4EF9EME

Chembl:

428561

Synonyms:

DMFP (18F)

Iupac Name:

5-(3-fluoropropyl)-2-methoxy-N-(2S)-1-prop-2-enylpyrrolidin-2-ylmethyl]benzamide| C=19 | H=27 | F=1 | N=2 | O=2| SMILES = COC1=C(C=C(C=C1)CCCF)C(=O)NC[C@@H]2CCCN2CC=C| StdInChI = 1S/C19H27FN2O2/c1-3-11-22-12-5-7-16(22)14-21-19(23)17-13-15(6-4-10-20)8-9-18(17)24-2/h3,8-9,13,16H,1,4-7,10-12,14H2,2H3,(H,21,23)/t16-/m0/s1| StdInChIKey = VPBJNBUDASILSQ-INIZCTEOSA-N}}

Desmethoxyfallypride is a moderate affinity dopamine D₂ receptor/D₃ receptor antagonist used in medical research, usually in the form of the radiopharmaceutical [F-18]-desmethoxyfallypride (DMFP(¹⁸F))^{[1] [2]} which has been used in human studies as a positron emission tomography (PET) radiotracer.^{[3] [4]}

References

Notes and References

1. Mukherjee J, Yang ZY, Brown T, Roemer J, Cooper M . 18F-desmethoxyfallypride: a fluorine-18 labeled radiotracer with properties similar to carbon-11 raclopride for PET imaging studies of dopamine D2 receptors . Life Sciences . 59 . 8 . 669–78 . 1996 . 8761017 . 10.1016/0024-3205(96)00348-7 .
2. (S)-N-((1-Allyl-2-pyrrolidinyl)methyl)-5-(3-[¹⁸F]fluoropropyl)-2-methoxybenzamide . 2004 . 20641474 . Leung . K. . Molecular Imaging and Contrast Agent Database .
3. Gründer G, Siessmeier T, Piel M, Vernaleken I, Buchholz HG, Zhou Y, Hiemke C, Wong DF, Rösch F, Bartenstein P . 6 . Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride . Journal of Nuclear Medicine . 44 . 1 . 109–16 . January 2003 . 12515884 .
4. Siessmeier T, Zhou Y, Buchholz HG, Landvogt C, Vernaleken I, Piel M, Schirrmacher R, Rösch F, Schreckenberger M, Wong DF, Cumming P, Gründer G, Bartenstein P . 6 . Parametric mapping of binding in human brain of D2 receptor ligands of different affinities . Journal of Nuclear Medicine . 46 . 6 . 964–72 . June 2005 . 15937307 .