| Desideria Ocampo Arriola | |
| Term Start: | February 8, 1898 |
| Term End: | April 9, 1910 |
| Term Label: | In role |
| Predecessor: | Algeria Benton |
| Successor: | Mercedes Llerandi |
| President: | Manuel Estrada Cabrera |
| Birth Name: | Desideria Ocampo Arriola |
| Birth Date: | 1861 |
| Death Date: | April 9, 1910 (aged) |
| Spouse: | Manuel Estrada Cabrera |
| Children: | 2 |
Desideria Ocampo Arriola (1861 – April 9, 1910) was the wife of President Manuel Estrada Cabrera, and served as First Lady of Guatemala during his presidency. She was daughter of Gabriel Ocampo and María Encarnación Arriola She died in France in April 1910. She had two children with the President Estrada Cabrera.[1] [2]