| Official Name: | Desaguadero |
| Native Name: | Huchusuma Chakamarka |
| Pushpin Map: | Peru#Bolivia |
| Pushpin Label Position: | bottom |
| Subdivision Type: | Country |
| Subdivision Type1: | Region |
| Subdivision Name1: | Puno Region (PE) |
| Subdivision Type2: | Province |
| Subdivision Name2: | Chucuito Province (PE) |
| Subdivision Type3: | District |
| Subdivision Name3: | Desaguadero District (PE) |
| Subdivision Type4: | Department |
| Subdivision Name4: | La Paz Department (BO) |
| Subdivision Type5: | Province |
| Subdivision Name5: | Ingavi Province (BO) |
| Subdivision Type6: | Municipality |
| Subdivision Name6: | Desaguadero Municipality (BO) |
| Leader Title: | Mayor |
| Leader Name: | Gumercindo Pari Escobar (2014-2018) (PE) |
| Leader Title1: | Mayor |
| Leader Name1: | Wilfredo Acarapi Aruquipa (2015-2020) (BO) |
| Established Title: | Foundation |
| Unit Pref: | Imperial |
| Population As Of: | 2001 |
| Population Total: | 2219 |
| Population Blank1 Title: | Ethnicities |
| Timezone1: | PET |
| Utc Offset1: | -5 |
| Timezone2: | BOT |
| Utc Offset2: | -4 |
| Coordinates: | -16.5667°N -69°W |
| Elevation M: | 3827 |
| Website: | munidesaguadero.gob.pe |
Desaguadero (Spanish for "channel, drain for drawing off superfluous water") or Chaka Marka (Aymara and Quechua for "bridge village") is a town on the Bolivian-Peruvian border. On the Bolivian side it is situated in the La Paz Department, Ingavi Province, Desaguadero Municipality, Desaguadero Canton. On the Peruvian side it lies in the Puno Region, Chucuito Province, Desaguadero District. Both parts of the town are united by a binational bridge.
The town is located 86 km from La Paz, 146 km from Puno city and 190 km from Juliaca.
Desaguadero has a tropical subalpine climate (Cwc).