| Des Griffin | |
| Fullname: | Denis Matthew Griffin |
| Birth Date: | 26 June 1882 |
| Birth Place: | Pyalong |
| Death Place: | Fitzroy, Victoria |
| Originalteam: | Pyalong |
| Statsend: | 1905 |
| Years1: | 1904 |
| Games Goals1: | 1 (0) |
| Years2: | 1905 |
| Games Goals2: | 1 (0) |
| Games Goalstotal: | 2 (0) |
Denis Matthew Griffin (26 June 1882 – 9 July 1969) was an Australian rules football player who played with St Kilda and South Melbourne in the Victorian Football League (VFL).[1]