Derrubone Explained

Derrubone is a prenylated isoflavone, a type of flavonoid. It was originally isolated from the Indian tree Derris robusta.^[1] Recent research indicates that it acts as an inhibitor of Hsp90 to its function as a chaperone protein.^[2]

Notes and References

1. East AJ, Ollis WD, Wheeler RE . Natural occurrence of 3-aryl-4-hydroxycoumarins. Part I. Phytochemical examination of Derris robusta(roxb.) benth. . J. Chem. Soc. C . 3 . 365–74 . 1969 . 3 . 10.1039/J39690000365 .
2. Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS . Derrubone, an inhibitor of the Hsp90 protein folding machinery . J. Nat. Prod. . 70 . 12 . 2014–8 . December 2007 . 18020309 . 10.1021/np070190s .