| Dernice | |
| Official Name: | Comune di Dernice |
| Coordinates: | 44.7667°N 12°W |
| Region: | Piedmont |
| Province: | Alessandria (AL) |
| Frazioni: | Montebore |
| Mayor: | Carlo Buscaglia |
| Area Total Km2: | 18.3 |
| Population Footnotes: | [1] |
| Population Total: | 182 |
| Population As Of: | 30 June 2017 |
| Population Demonym: | Dernicesi |
| Elevation M: | 600 |
| Saint: | Santa Lucia |
| Postal Code: | 15056 |
| Area Code: | 0131 |
Dernice is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 110km (70miles) southeast of Turin and about 40km (30miles) southeast of Alessandria. It is located across the ancient Salt road, a former commercial road between Genoa and the Padan Plain. It is the seat of production of the Montebore cheese, in the eponymous frazione. It was once home to a castle, now in ruins.
Dernice borders the following municipalities: Borghetto di Borbera, Brignano-Frascata, Cantalupo Ligure, Garbagna, Montacuto, and San Sebastiano Curone.