| Derek Watson | |
| Birth Date: | 1 May 1981 |
| Birth Place: | Anderson, South Carolina, U.S. |
| Number: | 43 |
| Status: | Active |
| Import: | yes |
| Position1: | Running back |
| Height Ft: | 6 |
| Height In: | 0 |
| Weight Lb: | 223 |
| College: | South Carolina State |
| High School: | Palmetto |
| Nfldraftedyear: | 2003 |
| Nfldraftedround: | Undrafted |
| Playing Years1: | 2003 |
| Playing Team1: | New England Patriots |
| Playing Years2: | 2005 |
| Playing Team2: | Tampa Bay Buccaneers |
| Playing Years3: | 2009 |
| Playing Team3: | Calgary Stampeders |
| Career Footnotes: | |
| Career Highlights: | |
| Cfl: | 2767 |
| Nfl: | WAT328605 |
Derek Watson (born May 1, 1981) is a former professional Canadian football running back for the Calgary Stampeders of the Canadian Football League (CFL). He was signed by the New England Patriots as an undrafted free agent in 2003. He played college football for the South Carolina State Bulldogs and the South Carolina Gamecocks. He attended high school at Palmetto High School in Williamston, South Carolina.
Watson has also played for the Tampa Bay Buccaneers.